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Drug-Associated Alopecia (Hair Loss) in Men

     

OVERVIEW. In today’s society, we take more and more medicine, and alopecia caused by medical treatments has continuously increased over the past fifty years. The medical substances reach the hair reproduction cells via the blood.

     

When they are negative for the hair, the intensity of their action depends on the dosage, the length of the treatment, the person’s personal characteristics and sensitivity to hair problems.

CONTENTS
linkThree types of alopecia caused by medicine
linkImportance of the diagnosis
linkDrugs that present a risk for your hair

 

Three types of alopecia caused by medicine

1. Tellogen effluvium, the most common
In medical terms, telogen effluvium means that more hair than usual goes into its renewal phase. In other words, the hair’s life will be shortened by the medicine’s negative impact. The hair will start to fall within 2 to 4 months following the beginning of the treatment. The hair loss will be diffuse, throughout the scalp, and reversible when the treatment ends, but will return if the treatment is resumed.

2. Anagen efflivium
It leads to a usually faster and more serious alopecia. Here, the medical substance suddenly stops the hair’s development in the middle of its growing phase. Anagen effluvium mainly occurs with treatments prescribed for anti-cancer chemotherapy (linkFAQ Chemotherapy and Hair Loss). As in the pervious case, the loss is reversible when the treatment ends, and reoccurs if it is resumed.

3. Androgenetic hair loss
A third category is ‘androgenising’ substances, contained in some hormonal treatments or corticoids. In those with a predisposition, such substances can trigger or worsen androgenetic alopecia. As a reminder, the alopecia is characterised by a shrinking of the hair follicles sensitive to androgens, thinning, and localised and very gradual hair loss

 

Importance of the diagnosis

Before ‘accusing’ the drugs, it is necessary to make sure that:

- The hair loss does indeed coincide, time-wise, with the intake of medicine.

- That is not the illness itself, or the stress that it causes, which have led to the hair loss, but rather the treatment itself. In that case, you should ask your physician if it is possible to replace the treatment (it sometimes is) with another molecule that does not cause hair loss.

 - That the substance in cause is officially registered as being negative for the hair. Some molecules indeed have an undeniable negative and almost systematic impact on the hair, and others have a definite but less systematic effect, in terms of the number of cases counted. Others, finally, are controversial, with only some marginal cases. An In-Depth Hair Diagnosis is recommended in the case of a doubt.

 

Drugs that present a risk for your hair

The chart below shows the main groups of drugs among which some molecules are likely to trigger alopecia.

IMPORTANT

To know if the specific medicine you are taking can cause a drug-associated alopecia, check, on your drug's package or leaflet, whether one of the molecules it is made of belongs to those that present a risk for your hair.


The list is not exhaustive but it does contain most medical molecules available in pharmacies and susceptible of causing alopecia (it does not contain treatments exclusively used in hospitals).

TYPE
OF MEDICAL DRUG

ESTIMATED
INCIDENCE

TYPE
OF ALOPECIA

Androgen hormones
Hormone Substitution Therapy (HST) to replace natural testosterone,
in the case of deficiency:
Androstanolone, Testosterone

Often

androgenetic

Antiarrhythmics
To suppress fast rhythms of the heart :
Amiodarone, Flecainide, Propafenone, Tocainide

Rarely

telogen effluvium

Anticoagulants
To make the blood more fluid:
Dicumarol, Heparin, Coumarin, Warfarin

Sometimes

telogen effluvium

Anticonvulsants/Antiepileptics
To decrease the core nervous system’s activity:
Carbamazepine, Ethotoin, Gabapentin,
Lamotrigine,
Phenytoin, Mephenytoin,
Tiagabine, Trimethadione, Paramethodione,
Valproate sodium

Sometimes

telogen effluvium

Anti-depressants
Amitriptyline, Amoxapine, Clomipramine,
Citalopram, Desipramine, Domipramine, Doxepin,
Fluoxetine, Fluvoxamine, Imipramine, Nortriptyline,
Paroxetine, Protriptyline, Sertraline, Trimpramine

Sometimes

telogen effluvium

Antifungals
To treat infections with fungi:
Fluconazole, Itraconazole, Liposomal amphotericin
Often,
if long treatment
& strong dosage

telogen effluvium

Antihistamines/Antiulcers
To treat peptic ulcer:
Cimetidine, Famotidine, Lansoprazole,
Omeprazole, Ranitidine
Rarely

telogen effluvium

Antihypertensions
To decrease arterial tension:
Benazepril, Captopril, Diazoxide, Enalapril,
Lisinopril, Quinapril

Rarely

telogen effluvium

Anti-inflammatory against gout crisis
Colchicine

Often, especially if strong dosage

telogen effluvium

Anti-inflammatory steroids - AIS
Synthesis corticosteroids :
Betamethasone, Cortisone, Dexamethasone,
Hydrocortisone, Methylprednisolone,
Prednisolone, Prednisone, Triamcinolone

Sometimes, if strong dosage and long treatment

androgenetic

Antimitotics
Anti-cancer chemotherapy

Often

anagen effluvium

Antithyroidals
To regulate the thyroid gland:
Carbimazole, Itriconazole, Methimazole,
Propylthiouracil, Thiouracil

Sometimes, if overdosage

telogen effluvium

Beta blockers
To block the adrenalin’s action:
Acebutolol, Atenolol, Betaxolol, Bisoprolol,
Carvedilol, Labetalol, Metoprolol, Nadolol,
Pindolol, Propranolol, Timolol

Rarely

telogen effluvium

Hypocholesterolemics/Hypolipidemics:
To decrease the level of cholesterol
and/or triglycerides:
Atorvastatin, Ciprofibrate, Clofibrate,
Gemfibrozil, Lovastatin, Simvastatin, Statin

Sometimes

anagen
effluvium

Gold salts
An antirheumatic agent to cure polyarthritis:
Auranofin, Leflunomide, Methotrexate,
Sulfasalazine

Very often

telogen effluvium

Interferons alpha:
To regulate the immune system

Very often

telogen effluvium

Lithium:
A mood regulator

Very often

telogen effluvium

Neurolepics
To treat psychosis:
Haloperidol, Loxapine, Maprotiline,
Olanzapine, Risperidone
Rarely

telogen effluvium

Non-Steroidal Anti-inflamatories (NSAI)
Against pain and rheumatism:
Fenoprofen, Ibuprofen, Indomethacine, Ketoprofen, Meclomen, Nabumetone, Naproxen, Oxaprozin, Piroxicam, Sulindac

Very rarely

telogen effluvium

Retinoids
To cure serious forms of acne, seborrhea and psoriasis:
Acitretin, Etretinate, Isotretinoin, Retinoids,
Retinol, Vitamin A (if overdosage)

Often

telogen effluvium

Thyroidian hormones
To treat hypothyroidism:
Levothyroxine, Liothyronine

Sometimes,
when poorly
balanced dosage

telogen effluvium


Other types of drugs where some molecules favouring alopecia can be found: antibiotic, antigonadotropic, antihelminthic, antimigraine, antineoplastic, antimalarian, antiparkinsonian, antirheumatism, antiviral, immunomodulators, immunosupressors, conversion enzyme inhibitors, neuroleptic…


FOR FURTHER INFORMATION:
link
Men's Telogen Effluvium ((Diffuse Hair Loss)
linkChemotherapy and the Hair
linkCholesterol and Hair Loss
linkHypertension and Androgenetic Alopecia
linkThyroid Problems and Hair Loss
linkThinner and Fewer Regrowing Hair (with sketches). What To Do

FOR TREATMENT:
linkHair Growth and Regrowing: Where Exactly to Act ?
linkHair Loss Treatments FAQ
linkCLAUDERER Anti-Hair Loss Treatments
linkClauderer in-Depth Hair Diagnosis

Treat your Hair to the French Touch!

linkClauderer Archives

 

 

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