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The Impact of Androgen Hormones on Hair Loss
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OVERVIEW. Androgen hormones can have a crucial impact on women's hair loss. In this section, we go through the metabolism that takes place within the hair follicle in order to better understand how the treatments will be able to neutralise it. |
CONTENTS
1- Women and Androgen
2- Androgen in the Hair Follicle
3- Genetic Incidence
4- Biological Observation
5- Inhibiting Treatment
1- Women and Androgen
'Androgen' is the generic term referring to all the male sexual hormones. Those hormones (the main one being testosterone) are the cause for most hair problems in men, but also in women.
Here is why: Our hair develops and lives under hormonal dependence. For women, female sexual hormones, i.e., estrogen and progesterone, are the main factors for that development. But women also produce testosterone, although 20 times less than men do. In case of a natural predisposition, that small quantity, secreted by their surrenal glands (60%) and ovaries (40%) can have a negative impact on the hair's normal renewal.
However, unlike men, women never turn bald. That is because their emission of androgen is countered by that of estrogen, which has an anti-androgen function.
2- Androgen in the Hair Follicle
Testosterone reaches the hair follicle via the blood stream. It then fixes itself on the Androgen Receptors (AR), which is found in the four key locations of hair production:
. The papilla through which the blood arrives,
. The matrix that generates the keratin cell and transforms it into hair,
. The epithelial sheath which guides the forming hair stem,
. The sebaceous gland finally, which is entirely under androgen controle. |
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Healthy Follicle
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As soon as it goes through its target receptors, testosterone links itself to an enzyme called 5 alpha-reductase (5a), which metabolises it into a new androgen, DHT (dihydrotestosterone). On a healthy follicle, the two substances associate themselves with no consequence and are not in the way of the physiological development of women's hair.
3- Genetic Incidence
Problems occur in the case of genetic predisposition: when that is the case, there is a mutation of the hair follicle submitted to the negative influence of one or several so-called alopecia genes. There is then a series of consequences: the genes stimulate the activity of the 5 alpha-reductase, which itself triggers a much stronger secretion of DHT. This increased secretion unsettles the follicles' work, leads to their progressive deterioration and finally has a negative impact on the hair's normal development.
- The alopecia genes can be transmitted to a daughter through her mother's genetic code, or her father's, or both. That does not mean that the child, whose genetic capital will include that heritage, will necessarily tend to lose her hair later: nothing is simple with regards to genetics, and a child can carry the genes without they ever taking action. It will partly depend on the whole of her personal factors, both physiological and physiological, which will determine whether or not the condition is developed.
- It is not the quantity of secreted testosterone that matters (except from rare cases of severe hirsutism) but rather how 'ravenously' it is received and then transformed by the genetically programmed follicles. In other words, it is not a hormonal condition but rather one of the receptor.
- To this day, several teams of geneticists around the world work on trying to isolate the alopecia gene. When they succeed, the condition should be able to be eradicated by  Genic Therapy.
4- Biological Observation
The biological observation of the damage caused by this genetic disruption has made considerable progress over the past 10 years. By going over the 4 key locations where the 5 alpha-reductase stays in the hair follicle, we now know how the enzyme responsible for the attack triggers it on all fronts.
1- The papilla decreases in volume, and the blood flow is diminished: the follicle will progressively shrink.
2- The matrix, which is less irrigated, and the pace of which is upset, diminishes its time spent on keratin production: the hair that will result from it will have been generated and renewed too fast, and will be increasingly puny after each renewal.
3- The cells of the external epithelial sheath differentiate themselves with more difficulty: the stem in formation anchors itself less firmly to the follicle.
4- In this less differentiated structure, the secretion of sebum can invade the inside of the hair follicle, instead of evacuating it outside the skin: the infiltration then smothers the root with toxins, which contribute to further shrinking it.
It is therefore the follicle's excessive responsiveness (due to its constitution) to androgen, which leads to that type of alopecia. The combination of the terms 'gene' and 'androgen' explain why such a type of hair loss is qualified as 'androgenetic'.
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Androgenetic Follicle
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Related Info Files:
Hair Loss - Women's Androgenetic Alopecia
Thinner and Fewer Regrowing Hair (Women)
5- Inhibiting Treatment
According to our statistics, the best results are obtained by associating a local Clauderer Treatment (100% natural molecules) to an anti-androgen hormonal treatment (by oral intake). The former cleanses the hair follicles and brings compensating vitamins to the roots, which are needed for the hair's anchorage and the regrowing hair's strength. The latter (if the the diagnosis concludes that it is useful), weakens the Testosterone - 5 alpha-reductase connection and reduces the secretion of DHT.
IMPORTANT:
For women who cannot or do not want to follow a hormonal treatment, the Local Clauderer Treatment, with its exclusive formula made of anti-androgen plants and very active essential oils is often enough to neutralise the 5 alpha-reductase and to stop the hair loss In vivo test of Clauderer anti-hair loss treatment
ANTI-HAIR LOSS
CLAUDERER
TREATMENT |
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 Clauderer Milks
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Stimulate the blood circulation and purify the roots by evacuating their toxins outside the hair. |
Clauderer Concentrates |
Bring to the roots the substances the forming keratin needs, in order to make up for the DHT's negative effects.
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HOTMONAL
TREATMENT
(ORAL INTAKE) |
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*The name of Androcur may vary from one country to another: Cyprostat, Cyproteron, Procur, Cyprone, Cyprohexal, Ciproterona...
FOR FURTHER INFORMATION:
'Androgenetic': A Word that Scares Women...
List of Contraceptives (with androgen/anti-androgen rating)
List of HST (with androgen/anti-androgen rating)
Anti-Hair Loss Clauderer Treatments
Hair Growth and Regrowth: Where Exactly to Act?
In-Depth Clauderer Hair Diagnosis
Treat your Hair to the French Touch!
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