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The Impact of Androgen Hormones on Hair Loss


     

OVERVIEW
Androgen hormones can have a crucial impact on men's hair loss. In this section, we go through the metabolism that takes place within the hair follicle in order to better understand how the treatments will be able to fight it.


CONTENTS
1linkDefinition of Androgen
2link Androgen in the Hair Follicle
3link The Notion of Genetic Predisposition
4link Biological Observation
5link Inhibiting Treatment

1- Definition of Androgen

'Androgen is the generic term referring to all the male sexual hormones.  The main one is testosterone. Those hormones, 95% of which are secreted by the testicles and 5% by surrenal glands, are the main cause of men's hair loss.

2- Androgen in the Hair Follicle

Testosterone reaches the hair follicle via the blood stream. It then fixes itself on the Androgen Receptors (AR), which is found in the four key locations of hair production:

. The papilla through which the blood arrives,

. The matrix that generates the keratin cell and transforms it into hair,

. The epithelial sheath, which guides the forming hair stem,

. The sebaceous gland, finally, which is entirely under androgen controle.

   

root
Healthy Follicle

As soon as it goes through its target receptors, testosterone links itself to an enzyme called 5 alpha-reductase (5a), which metabolises it into a new androgen, DHT (dihydrotestosterone). On a healthy follicle, the two substances associate themselves with no consequence and are not in the way of the physiological development of men's hair.

3- The Notion of Genetic Predisposition

Problems occur in the case of genetic predisposition: when that is the case, there is a mutation of the hair follicle submitted to the negative influence of one or several so-called alopecia genes. There is then a series of consequences: the genes stimulate the activity of the 5 alpha-reductase, which itself triggers a much stronger secretion of DHT. This increased secretion unsettles the follicles' work, leads to their progressive deterioration and finally has a negative impact on the hair's normal development.

•  The alopecia genes can be transmitted to a son through his father's genetic code, or his mother's, or both. That does not mean that the child, whose genetic capital will include that heritage, will necessarily tend to lose his hair later: nothing is simple with regards to genetics, and a child can carry the genes without they ever taking action. It will partly depend on the whole of her personal factors, both physiological and physiological, which will determine whether or not the condition is developed.

•  It is not the quantity of secreted testosterone that matters but rather how 'ravenously' it is received and then transformed by the genetically programmed follicles. In other words, it is not a hormonal condition but rather one of the receptor.

• To this day, the alopecia genes have still not been isolated. When they are, the condition should be able to be totally eradicated by linkGenic Therapy. Several teams of geneticists around the world are currently working on this around the world.


Biological Observation

1- The papilla decreases in volume, and the blood flow is diminished: the follicle will progressively shrink.

2-
The matrix, which is less irrigated, and the pace of which is upset, diminishes its time spent on keratin production: the hair that will result from it will have been generated and renewed too fast, and will be increasingly puny after each renewal.

3-
The cells of the external epithelial sheath differentiate themselves with more difficulty: the stem in formation anchors itself less firmly to the follicle.

4- In this less differentiated structure, the secretion of sebum can invade the inside of the hair follicle, instead of evacuating it outside the skin: the infiltration then smothers the root with toxins, which contribute to further shrinking it. 

It is therefore the follicle's excessive responsiveness (due to its constitution) to androgen, which leads to that type of alopecia. The combination of the terms 'gene' and 'androgen'  explain why such a type of hair loss is qualified as 'androgenetic'. 

   

toxins
Androgenetic Follicle


FOR FURTHER INFORMATION:
linkHair Loss - Men's Androgenetic Alopecia
linkThinner and Fewer Regrowing Hair (Men)... What Can be Done?

5- Inhibiting Treatment

According to our statistics, the best results are obtained by associating a local Clauderer Treatment (100% natural molecules) to an anti-androgen hormonal treatment (by oral intake). The former cleanses the hair follicles and brings compensating vitamins to the roots, which are needed for the hair's anchorage and the regrowing hair's strength. The latter (if the link diagnosis concludes that it is useful), weakens the the Testosterone - 5 alpha-reductase connection and reduces the secretion of DHT.

ANTI-HAIR LOSS
CLAUDERER
TREATMENT


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link Clauderer Milks

Stimulate the blood circulation and purify the roots by evacuating their toxins outside the hair.

linkClauderer Concentrates

Bring to the roots the substances the forming keratin needs, in order to make up for the DHT's negative effects.

IMPORTANT :
For those who are reluctant to follow a hormonal treatment, the Local Clauderer Treatment, with its exclusive formula made of anti-androgen plants and very active essential oils (without side effects) is often enough to neutralise the 5 alpha-reductase and to stop the hair loss linkIn vivo test of Clauderer anti-hair loss treatment

HOTMONAL
TREATMENT
(ORAL INTAKE)


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linkPropecia® (finasteride)

Anti-androgen inhibiting the 5-alpha-reductase, Type II

linkAvodart® (dustasteride)

Anti-androgen inhibiting the 5-alpha-réductase, Type I and II




FOR FURTHER INFORMATION:
linkCLAUDERER Anti-Hair Loss Treatments
linkHair Growth and Regrowing: Where Precisely to Act?
linkIn-Depth Clauderer Hair Diagnosis

Treat your Hair to the French Touch!

linkClauderer Archives

 

 

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